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Description
S-RMab® Estrogen Receptor α Recombinant Rabbit mAb (SDT-R371)Product Specification Host Rabbit Antigen Estrogen Receptor Synonyms Estrogen receptor, ER, ER alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1 Location Cytoplasm, Nucleus, Cell membrane Accession P03372 Clone Number SDT R371 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | Estrogen Receptor α |
| Synonyms | Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1 |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P03372 |
| Clone Number | SDT-R371 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, ICC |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | null |
| ICC | 1:500 | null |
Background
Estrogen receptor alpha (ERα), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of estrogen receptor, a nuclear receptor (mainly found as a chromatin-binding protein) that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1 (Estrogen Receptor 1); The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. ERα plays a role in the physiological development and function of a variety of organ systems to varying degrees, including the reproductive, central nervous, skeletal, and cardiovascular systems. Accordingly, ERα is widely expressed throughout the body, including the uterus and ovary, male reproductive organs, mammary gland, bone, heart, hypothalamus, pituitary gland, liver, lung, kidney, spleen, and adipose tissue. Genetic polymorphisms in the gene encoding the ERα have been associated with breast cancer in women, gynecomastia in men and dysmenorrhea. In patients with breast cancer, mutations in the gene encoding ERα (ESR1) have been associated with resistance to endocrine therapy, especially aromatase inhibitors.
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4.5 ★★★★★
Based on 803 reviews
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Product Reviews
★★★★★ 3
OK for the price, but overall comfort is avergae
Size: 934-Z, Color: Mustard
Easy to put together, color (mustard) accurate to images, and while I understand this is not a high-end chair, I feel like it still needs to be rated for its quality.
Pros: the seat cushions are fairly comfortable and it rolls well. Adjustable footrest is easy enough and mostly sturdy.
Cons: For a tall office chair, it doesn't go up high enough. I actually had to lower my standing desk to sit at it, which then isn't where I want it when I'm standing now. It's also a bit wobbly. The seat area's attachment to the post isn't as solid as it should be for a tall chair, so while sitting, it does tend to lean/slope forward and wobble side to side. The lumbar support is not adjustable, so I'm not even really sure what it does. And the armrests are not very comfortable to use. Since they are hard plastic, they are just a bit too rigid to rely on for any comfort. They are basically there to hold on to when you're getting out of the chair.
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Reviewed in the United States on May 29, 2026
★★★★★ 4
Good Value for a Tall Chair
Size: 934W-Z, Color: White
I have received this chair just today and would like to give my first impressions of it.
Height is super adjustable as well as the foot rest. My desk is very tall (~34 inches vs standard ~29 inches) and does not suit a standard height chair. This chair's height is enough to sit comfortably at mybut also still having adjustment to be even higher.
Lumbar support is a manual adjustment that can be adjusted by sliding the lumbar piece up or down and it seems it can be tiled as well.
No reclining feature or slight backrest tilt adjustment. I'm used to my chairs reclining so it feels a little awkward siting in a flat base and straight backrest. I feel like I'm sitting too forward or leaning forward slightly but is probably something I can get use to.
Easy to put together and feels very sturdy. Plastic parts of chair are made from a really sturdy plastic, like playhouse plastic materials. Wheels roll around carpet easily. Mesh seems to be a strong material, though the mesh feels kind itchy on bare skin.
Overall, I think this is a good chair to get if you're needing a tall chair for a good value and can sacrifice no backrest tilt.
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Reviewed in the United States on December 3, 2025
★★★★★ 5
Unexpectedly great chair - easily adjusting it to suit changing day-to-day needs makes it incredible
Color: Black Rhythm
The bottom line on this chair is that it is unexpectedly miraculous. After just 3 days, I've found it is unconventionally comfortable and the thing that makes it unique is that it renders adjusting it a normal part of its usage. I was originally like most folks, I presume - set the chair and then see how it does - but this chair demands that you use its intuitive controls to change things around as your needs change during the day. It is so easy to do, and that is where the magic is.
I graduated from an excellent budget chair, the Alera Elusion high-back that is very adjustable. After over 5 years of pretty heavy usage, though, it was showing its wear, and I was really starting to feel the cushion every time I sat on it. I also started to experience some neck, shoulder, and lower back discomfort, and decided it was time to graduate to a better solution.
I did not consider the Embody chair initially. At first glance, it looked a bit weird, and it was also on the expensive side, so I blew right past it. My initial starting point was the Aeron. I had used one at work years ago, and I recalled its adjustability. My body was much younger when I had used it, so I didn't experience its ergonomic benefits as well as I should have. I also looked at Steelcase models as they had some good reviews. Steelcase didn't fit my requirements as well as the Herman Miller solutions, so I gravitated strongly to the Aeron and was about to push the trigger on the order. A last second search on YouTube led me to the Embody and I was intrigued because of a couple of factors: the intuitiveness of the controls and the emphasis on the flexibility of the back and seat. The people that loved it REALLY loved it, and that, compounded with the Herman Miller return policy interested me enough to try it.
So, here are some findings from the past 3 days:
First, the seat is incredibly comfortable. The pixellated solution flexes with the weight that is applied to it, and it makes you feel as though you are suspended with no uncomfortable pressure points - this completely resolved the issue I was facing with the old Alera. It breathes well, is cool, and just invites you to sit down. The seat length adjustment required a little strength, but works well - you are not stuck with just the default length that might be either too small or too large. I had to adjust a couple of times to get just the right length. Once set, I don't foresee having to adjust it often.
Second, I have found that I change the recline setting on the chair frequently. When I am typing, I set it so that it is relatively rigid, and when I am mostly reading, I set it so that it flexes more. There are several aspects to this - for typing, I set the tilt limiter to the position that allows the least possible movement or the next step down. I tighten the recline knob to keep me more upright, and adjust the back to a comfortable setting. It is all really easy, and the chair gives immediate feedback to ensure a good setting. When I am reading, I set the recline to setting 2 or 3 (more recline) and relax the recline a bit. That gives me the opportunity to lean back as needed and move around, with full support. If I am watching YouTube, I go to the most relaxed recline setting, and adjust the back to a less aggressive setting, and it is very comfortable. Setting/resetting all of the controls is responsive, easy, and intuitive. I never thought that this would be so required in a good seating experience.
Third, I fiddled with the height of the chair to find the most comfortable setting. I use an iMovR standing desk and a Kinesis Advantage keyboard. I initially set the chair/desk combination so that my feet were flat on the ground and so that my forearms were angled downward slightly - supposedly more ergonomic. I ended up with some discomfort in my right wrist. Through experimentation, I found that raising my table or lowering the chair so that my forearms are angled a bit upwards got me in the correct wrist position for the keyboard, since it has wells. I am more upright with these settings, and am finding that my back is much more in contact with the chair, providing great and flexible support. This may not work well for folks using normal keyboards, but it is great with the Advantage. I also adjusted the height of the monitor so that it is a little higher than most ergonomic folks would recommend. I had found that by keeping the top of the monitor strictly at eye level as recommended, I was moving my head down to read the lower part of the screen, and this was causing some neck discomfort. My current setting is very comfortable.
I have spent long hours in this chair over the past few days, and I am very impressed. My experience with the Alera and Aeron, both excellent chairs, is that they unwittingly promote the initial set and don't adjust paradigm, simply because adjustments, though technically possible, are not as integrated into the seating experience - you have to bend, get up, or twist unnaturally to do the adjustment. The Embody chair, on the other hand, encourages adjustments while you are in the seated position because the controls are few and easy to reach. This allows adjustments that correlate to the changing needs of our bodies throughout the day with immediate feedback because all of the controls are so well placed and simple to use. Flexibility and consistent support are inherently part of the design.
No doubt that this chair is expensive, but with the generous 12 year warranty, this chair is about as good an investment you can make for your back and your general health if you spend significant time in a chair.
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Reviewed in the United States on May 16, 2020
★★★★★ 5
The perfect office chair for me
Color: Berry Blue Balance
I’ve always wanted a good ergonomic chair for my home office but, since most of my time was spend in the office prior to COVID, I couldn’t really justify spending the money. When COVID shutdown the office and remote work meant spending 10 – 12 hours in my cheapy chair, it was time to look for the home office chair of my dreams.
I really had three chairs in mind; the Herman Miller (HM) Aeron, the HM Embody and the Steelcase (SC) Gesture. Why did I settle on the HM Embody?
• Seating Material – In the office, the AC is always cranked up so you don’t really get hot even when sitting for long periods of time, so breathability of the seat doesn’t seem to be as much of a problem. Normally, at home you don’t have the AC up as high so there is a higher chance that your butt and back of your thighs will get hot and sweaty. The Gesture is a more traditional office seat design with tight woven fabric on a foam cushion seating surface. You could image it getting hot. The Embody has what I would call an airframe. The seating material is a sort of open weave, porous fabric (Balance fabric) and stretched over a frame. This allows air to circulate freely through the seat. Aeron is similar but a mesh. In this area Embody was chosen because, if you are wearing shorts (no one sees below our chest on a vid call. . . right?) the mesh could be rougher on your skin and not be as comfortable. This turned out to be true. The Embody fabric was much softer to the touch, yet just as breathable as the Aeron mesh. Durability of the fabric is very good and after almost 2 years of daily use there is no signs of wear or color fading.
• Ergonomic adjustments – All three chairs have similar seat adjustments with one exception. The Aero and Gesture have adjustable lumbar supports. The Embody doesn’t. It has a sort of lattice structure that has curvatures to cradle your back. You can adjust the angle of the backrest to come in closer to your back, thus giving more lumbar support (and upper back support) or away for less. How this would actually feel was a big question at time of purchase, but I can tell you that it works fine for me and provide the support I need. I also like how the backrest tapers towards the middle. This allows more freedom of movement of your arms and elbows.
• Arms - The arms should be part of the ergonomics, but although the Embody has less adjustments here it still provides good ergonomic support. The arms on the Embody move up and down and narrower to wider. They don’t slide fore/aft or pivot in/away from you. The limited arm adjustments have not been a problem. I can comfortably use the armrests all day. If you want more arm adjustability, the Gesture offers more, but from my use of the chair in the office, some of it like the pivot function, just get in the way.
• Seat structure – All three have solid, durable structures. I have not had any problems with the base, casters, or seat frame itself. I expect it to last a long time. Now, everybody’s body is shaped differently and that matters when choosing a chair. To my knowledge the Embody and Gesture only come in one size while the Aeron is available in three. I am assuming that the Embody is designed to fit people within a certain average height and weight range. If you fall outside of that, the comfort and fit won’t be as good. In that case, you might want to look at the Aeron which offers different height adjustment ranges, seat widths, etc. You might also be a borderline so consider this example, I’m on the shorter side and with the Embody at its lowest position, I am just barely at the correct knee position. It works for me, but I have no margin. However, if I have chosen the Aeron size A, I would have additional space to lower the seat, but would also have to consider the narrower seat body.
To sum it up. The Herman Miller Embody was well worth the price paid. The seat is very comfortable, breathes well, offers great support and is built to last. I would recommend this chair to anyone who is looking for a premium quality ergo chair, but as you can see, there are others that are just as good and may even fit your better. I hope I have been able to give you a good comparison that can show you the difference between a few of them so you can determine what is most important to you. However, no review can ever replace in seat (no pun intended) experience. If at all possible, find place where you can actually try them out. This is my 100%, guaranteed, best recommendation!
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Reviewed in the United States on April 1, 2022
★★★★★ 1
Not for short people, as in 5'4"
Color: Black Rhythm
TLDR, this is a used so no warranty. You have to do some putting together, comes in a wide square box, came used that's for sure. Gas lift is wobbly and it costs $90 to replace, again no warranty with this chair buying from here. Not a good chair for someone short, and wearing 28 length pants, feet barely fully floor. Tends to make you lean back, so not a good work chair/competitive gaming chair. Lastly, not comfortable, too much ergonomics (doesn't feel ergonomic though, not for me), imagine trying to get work done and in discomfort, half of the discomfort is from the seat, so the discomfort is felt in the glutes.
I'm around 5'4". My glutes are uncomfortable and the mid back is uncomfortable.
The seat towards the end it has a lot of pressure so its not comfortable for glutes. It just lacks lower/mid back support, I sit as hips forward and upper back backwards it cannot be adjusted so the seat tilts forward which would probably help relive the discomfort in my glutes as well.
My feet barely fully on the ground, so just to give idea 5'4", I wear 28 length pants.
No tilt, so I'm sitting leaning backwards a lot, the seat edge curves up so uncomfortable on glutens, doesn't go down far enough either.
Not a good chair for a short person, but there is hardly chairs for short people too, very frustrating.
$1355, wobbly, still not a good chair for short person, some of the features are not present, forward tilt, the back piece does not go back down by itself either, it leans back with the seat. The back rest it only goes in from the very low back, it makes you lean back even more. Probably a gamer chair sitting leaning backwards, but I play video games too. If your playing competitively your not leaning back your comfortably forward. This chair doesn't have that. This is more an MMORPG chair than a competitive video game player chair. Or someone who does IT work and has to get done, seat forward comfortably, not leaning back.
I'd list the pros, but the cons far outweigh the pros and I paid $1355 for this, there should be little to no cons. Chair is not comfortable so it doesn't matter what the pros are, its not comfortable for a short person. I need forward tilt on the seat. Leaning back the seat, the whole seat leans back, so the forward edge leans back too, meaning my feet are not fully/comfortably on the ground anymore.
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Reviewed in the United States on July 9, 2024