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Description
4-1BB/TNFRSF9 His Tag Protein, RatProduct Specification Species Rat Synonyms T cell antigen ILAILA4 1BB Ligand ReceptorCD137 AntigenCDw137CD137Interleukin Activated Receptor Homolog Of Mouse Ly63Tumor Necrosis Factor Receptor Superfamily Member 9Homolog Of Mouse 4 1BBReceptor Protein 4 1BBT Cell Antigen ILA Accession Q4W8J3 Amino Acid Sequence Thr24 Gln187, with C terminal His Tag Expression System HEK293 Molecular Weight 28 40kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g
Product Specification
| Species | Rat |
| Synonyms | T-cell antigen ILA，ILA，4-1BB Ligand Receptor，CD137 Antigen，CDw137，CD137，Interleukin-Activated Receptor， Homolog Of Mouse Ly63，Tumor Necrosis Factor Receptor Superfamily， Member 9，Homolog Of Mouse 4-1BB，Receptor Protein 4-1BB，T Cell Antigen ILA |
| Accession | Q4W8J3 |
| Amino Acid Sequence | Thr24-Gln187, with C-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 28-40kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90. 2. Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88. |
Background
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. The best characterized activity of CD137 is its costimulatory activity for activated T cells.
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