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Description
MUC18/CD146 His Tag Protein, HumanProduct Specification Species Human Synonyms METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM Accession P43121 Amino Acid Sequence Val24 Gly559, with C terminal 10*His
Product Specification
| Species | Human |
| Synonyms | METCAM, CD146, Melanoma cell adhesion molecule, MCAM, Cell surface glycoprotein MUC18, Gicerin, MUC18, MelCAM, HEMCAM |
| Accession | P43121 |
| Amino Acid Sequence | Val24-Gly559, with C-terminal 10*His VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 80-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Mills L. et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-5114. 2、Taira E. et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-387. 3、Fritzsche F R. et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-464. |
Background
CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
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Exchange/Return Notes
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4.3 ★★★★★
Based on 1520 reviews
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Product Reviews
★★★★★ 5
FINALLY a decent phone mount!!!
I’ve tried about 5 different phone mounts in my 2018 Tacoma and ended up throwing them all away. They’re either too bulky, too weak to hold the phone, awkward or just won’t stay in place. I won’t install a holder that requires adhesive or screws into the dash (or anywhere) in my truck. This holder is the answer. Fits perfectly, doesn’t damage your vehicle. Holds the phone really solidly. This is a very sturdy mount.
It’s a bit pricy in comparison to other phone mounts out there. IMO, it’s worth every penny. Materials are far superior to your typical mount, which I’m sure drives up the manufacturing costs. Again, worth every penny. Also, it’s a small business based in the US. Love supporting our small businesses.
GREAT MOUNT!!!
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Reviewed in the United States on November 11, 2022
★★★★★ 5
This is it
For the longest time I’ve STRUGGLED with finding a mount the works in my Tacoma. I don’t do off reading but every mount I use just can’t hang!! I got this and immediately impressed with the build quality. It’s entirely metal and can tell it’s sturdy. It took me 1 minute to install and the give you the one tool you need to install. I have an iPhone 13 Pro Max that baby isn’t going anywhere. You can adjust it with out unscrewing anything and it stays put. If you have a Tacoma stop wasting money on cheap mounts this is the last one you need I promise you
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Reviewed in the United States on June 29, 2024
★★★★★ 5
The only phone mount for a taco
This is a really quality product. So quality that I wish they made this for some of my other cars, I don't ever wanna use another phone holder. I was a bit skeptical on the longevity of the spring that holds it open, but a few months later and it feels just as sturdy as new. Fit is immaculate, the phone stays put. Worth the price. You will see when you see the machine finish on this product.
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Reviewed in the United States on March 25, 2025
★★★★★ 5
Fantastic Mount especially on rough Roads
Robust and discretely positioned mount. This mount is the real deal. It is by far the highest quality most stable mount that I've ever had in my Tacoma pickup. I also really like that it's positioned closer to the steering wheel in instead of in the windshield, making it easier to view. Very highly recommended!!
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Reviewed in the United States on January 27, 2026
★★★★★ 5
Perfecto Product!!
I rarely write reviews, however on this product I need too. This clearly is a pricey phone mount, but after reading so many reviews I went for it & purchased. After opening, I immediately could see & feel the quality of material used. Installation was surprisingly easy & quick to my Tacoma. The mount is very firm, sturdy, very adjustable, perfectly designed product. For as costly as this was, I have absolutely no regrets! Totally can recommend this product to anyone with a Tacoma within the stated production years. So as so many others have said accurately in reviews, I am beyond satisfied even with the cost in mind.
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Reviewed in the United States on June 8, 2023
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