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Description
CA125/MUC16 His Tag Protein, HumanProduct Specification Species Human Synonyms CA125, FLJ14303, MUC16, mucin 16 Accession Q8WXI7 1 Amino Acid Sequence Pro13810 Pro14451, with C terminal His Expression System HEK293 Molecular Weight 91 121kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CA125, FLJ14303, MUC16, mucin 16 |
| Accession | Q8WXI7-1 |
| Amino Acid Sequence | Pro13810-Pro14451, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 91-121kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Bast R C. et al. (1981) Reactivity of a Monoclonal Antibody with Human Ovarian Carcinoma. J Clin Investig. 68: 1331-1337. 2、Yin B W T. et al. (2001) Deciphering the Molecular Nature of Ovarian Cancer Biomarker CA125. J Biol Chem. 276: 27371-27375. 3、O’Brien T J. et al. (2001) The CA 125 gene: an extracellular superstructure dominated by repeat sequences. Tumour Biol. 22: 348-366. |
Background
CA125 (also known as MUC16) was first identified in 1981 by OC125, a mAb that had been developed from mice immunized with human ovarian cancer cells. The first cDNA clones were reported in 2001. CA125 is a very large membrane-bound cell surface mucin, with an average molecular mass between 2.5 and 5 million daltons. It is also heavily glycosylated with both O-linked and N-linked oligosaccharides. The peptide backbone of CA125 is composed of the N-terminal region, extensive Ser/Thr/Pro-rich tandem repeats (TR) with 156 amino acids each with both N- and O-glycosylations, a SEA domain with high levels of O-glycosylation and a C-terminal region with a short cytoplasmic tail. The expression of CA125 is associated with multiple systemic tumors (ovarian cancer, digestive system malignancy, tongue cancer, breast cancer, lung cancer, et al.). Serum CA125 is the most widely used method to detect recurrence and monitor response to treatment and is a sensitive tumor marker.
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